The INCENTIVE project is a partnership between Indian, European and US partners. Its main objective is to advance knowledge of the underlying mechanisms of poor responsiveness to influenza vaccines (IVs) and to develop two next-generation universal IVs.
Goals:
- Identifying the mechanisms of vaccine responsiveness by performing comprehensive profiling of responders and non-responders to licensed IVs to identify the mechanisms of vaccine responsiveness;
- Advancing the development of two next-generation vaccines by providing a proof-of-concept for vaccine efficacy in non-human primates for an antigen presenting cell-targeted nucleic acid vaccine and developing a computationally-optimized vaccine up to phase II clinical trials and vaccine efficacy in a controlled human challenge;
- Identifying predictive biomarkers of responsiveness to vaccination for new diagnostics;
- Implementing technology transfer;
- Health systems and investment analysis.
The project is running from August 1, 2020 until July 21, 2025 and is led by Helmholtz Centre for Infection Research, Germany.
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